Kouya ni Kemono Dokokosu
There's a fair amount of subtext and discussion about the line between man and beast and instinct as an analog for dharma. One of the main bad guys also has that zen thing going on where he effectively has superpowers because he skips thought and goes straight from intent to action. Fantastic art, lots of gory violence, native americans being dicks, and a cute monkey girl. What's not to like?